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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T67909 | TAK1 inhibitor | compound 13a | Topoisomerase |
TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively. TAK1 inhibitor showed good antibacterial activity with microphones ranging fro... | |||
T78766 | HDAC-IN-59 | HDAC | |
HDAC-IN-59 (compound 13a), a potent histone deacetylase (HDAC) inhibitor, enhances intracellular reactive oxygen species (ROS) production, induces DNA damage, arrests the cell cycle at the G2/M phase, and triggers the mi... | |||
T62458 | EGFR-IN-56 | ||
EGFR-IN-56 (Compound 13a) is a potent inhibitor of EGFR, acting on EGFRT790M (IC50: 541.7 nM) and EGFRT790M/L858R (IC50: 132.1 nM). EGFR-IN-56 blocks the cell cycle of cancer cells in the G2/M phase and induces EGFR-IN-5... | |||
T63110 | CBP/p300-IN-15 | ||
CBP/p300-IN-15 (compound 13a) is a potent inhibitor of p300 (IC50: 2.5 nM) and CBP (IC50: 28.0 nM). p300-IN-15 inhibits OVCAR-3 cells (EC50: 0.865 μM) and A2780 cells (EC50. 2.71 μM). 2.71 μM). CBP/p300-IN-15 can be used... | |||
T61977 | FLT3/D835Y-IN-1 | ||
FLT3/D835Y-IN-1 (compound 13a) is a orally active, and selective inhibitor of FLT3 and FLT3/D835Y, with IC50s of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 has anticancer efficacy, and has research value in AML (... | |||
T38446 | ROC-0929 | ||
ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s), effectively targeting hGX with an IC50 of 80 nM. It efficiently inhibits the phosphorylation of ERK1/2 and p-38. sPLA2s,... | |||
T79540 | HCA/VEGFR-2-IN-1 | Carbonic Anhydrase | |
hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual inhibitor targeting both Carbonic Anhydrase (CA) IX/XII and Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2). It exhibits Ki values of 4.7 nM for hCA XII and 8.3 nM... |